Publications

Hannah Fassel, Donald Tracy, Katie Louer, and Giannoula Lakka Klement

Insulin-like Growth Factor Receptor Inhibition as Maintenance Therapy for Metastatic Ewing Sarcoma

J Pediatr Hematol Oncol, 2016, 38(7), 563-569

Edward. A. Rietman, Jacob G. Scott, Jack A. Tuszynski, Giannoula Lakka Klement

Personalized anticancer therapy selection using molecular landscape topology and thermodynamics

Oncotarget, 2016;

Edward A. Rietman, John Platig, Jack A. Tuszynski, Giannoula Lakka Klement

Thermodynamic measures of cancer: Gibbs free energy and entropy of protein–protein interactions

J Biol Phys. 2016:1-12

Giannoula Lakka Klement

Eco-evolution of cancer resistance.

Sci. Transl. Med. 2016; 8, 327fs5.

Giannoula Lakka Klement, Knarik Arkun, Dalibor Valik, Tina Roffidal, Ali Hashemi, Christos Klement, Paolo Carmassi, Edward Rietman, Ondrej Slaby, Pavel Mazanek, Peter Mudry, Gabor Kovacs, Csongor Kiss, Koen Norga, Dobrin Konstantinov, Nicolas André, Irene Slavc, Henk van Den Berg, Alexandra Kolenova, Leos Kren, Jiri Tuma, Jarmila Skotakova, Jaroslav Sterba

Future paradigms for precision oncology

Oncotarget, 2016; 7(29), 46813-46831

J. Tyson McDonald, Christine Briggs, Heather Szelag, Michael Peluso, Douglas Schneider, Aleksandr Perepletchikov, Giannoula Lakka Klement, Ingolf Tuerk & Lynn Hlatky

Chronic low dose-rate radiation down-regulates transcription related to mitosis and chromosomal movement similar to acute high dose in prostate cells.

International Journal of Radiation Biology, 2014; 90: 231–240

Pilatova K., Zdrazilova-Dubska L., Lakka Klement G.

The Role of Platelets in Tumor Growth

Klin Onkol. 2012; 25 Suppl 2:2S50-7. PMID: 23581017

Tracy JC, Lakka Klement G, Scott AR. 

Interdisciplinary management of congenital infiltrating lipomatosis.

Int J of Ped Otorhinolaryngology 77 (2013) 2071–2074

Kareva I, Waxman DJ, Lakka Klement G. 

Metronomic chemotherapy: An attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance.

Cancer Lett. 2014 Dec 23. PubMed PMID: 25541061. Epub 2014/12/30. 

Rössler J, Saueressig U, Kayser G, von Winterfeld M, Lakka Klement G. 

Treatment of Gorham Stout Disease with a combination of sunitinib and taxol.

J Pediatr Hematol Oncol. 2015 Nov;37(8):e481-5.

 

Benzekry S., Tuszynski JA, Rietman EA, Lakka Klement G. 

Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks.

Biol Direct. 2015; 10: 32. Published online 2015 May 28. doi: 10.1186/s13062-015-0058-5, PMCID: PMC4445818

Afranie-Sakyi JA, Klement GL.

The toxicity of anti-VEGF agents when coupled with standard chemotherapeutics. 

Cancer Lett. 2015 Feb 1;357(1):1-7. PubMed PMID: 25449430. Epub 2014/12/03.

Prochazka V, Gumulec J, Chmelova J, Klement P, Klement GL, Jonszta T, Czerny D, Krajca J.

Autologous bone marrow stem cell transplantation in patients with end-stage chronical critical limb ischemia and diabetic foot.

Vnitr Lek.  2009  Mar;55(3):173-8. PubMed PMID: 19378841.

Klement GL, Yip TT, Cassiola F, Kikuchi L, Cervi D, Podust V, Italiano JE, Wheatley E, Abou-Slaybi A, Bender E, Almog N, Kieran MW, Folkman J.

Platelets actively sequester angiogenesis regulators.

Blood. 113(12):2835-42.  2009 Mar 19; Epub 2008 Nov 25.  PMID: 19036702

Gesundheit B, Parkin P, Greenberg M, Baruchel S, Senger C, Kapelushnik J, Smith C, Klement GL.

The Role of Angiogenesis in the Transformation of Plexiform Neurofibroma into Malignant Peripheral Nerve Sheath Tumors in Children with Neurofibromatosis Type 1.

J Pediatr Hematol Oncol 32(7):548–53  2010 [Epub ahead of print]  DOI: 10.1097/MPH.0b013e3181e887c7

Peterson JE, Zurakowski D, Italiano JE. Jr., Michel LV., Fox L, Klement GL, Folkman J.

Normal ranges of angiogenesis regulatory proteins in human platelets.

Am J Hematol. 85:487–493, 2010 [EPub ahead of print April 13,2010]

Burrows PE, Mulliken JB, Fishman SJ, Klement GL, Folkman J.

Pharmacological Treatment of a Diffuse Arteriovenous Malformation of the Upper Extremity in a Child.

J Craniofac Surg. Suppl 1:597-602. Erratum in: J Craniofac Surg. 2009 Sep;20(5):1629-30.  Mar;20, 2009  PMID: 19293678

Flaumenhaft R, Dilks JR, Richardson J, Alden E, Patel-Hett SR, Battinelli E, Klement GL, Sola-Visner M, Italiano JE Jr.

Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles.

Blood. 113(5):1112-21.2009 [Epub 2008 Sep 18] PMID:18802008

Almog N, Klement GL.

Platelet Proteome and Tumor Dormancy: Can Platelets Content Serve as Predictive Biomarkers for Exit of Tumors from Dormancy?

Cancers 2(2), 842-858;  2010 doi:10.3390/cancers2020842
Procházka V, Gumulec J, Jaluvka F, Salounová D, Jonszta T, Czerný D, Krajca J, Urbanec R, Klement P, Martinek J, Klement GL.
Cell Therapy, a New Standard in Management of Chronic Critical Limb Ischemia and Foot Ulcer.
Cell Transplant. Vol. 19, pp. 1413–1424  2010 Jun 7. [Epub ahead of print]  PMID: 20529449

Klement GL.

Platelet biomarkers in tumor growth.  

Current Proteomics.  2011  8(3)169-180

Klement GL, Kamen BA.

Nontoxic, fiscally responsible, future of oncology: could it be beginning in the Third World?

J Pediatr Hematol Oncol. 2011 Jan;33(1):1-3. doi: 10.1097/MPH.0b013e3182024918. PMID: 21164359

Almog N, Klement GL.

Platelet Proteome and Tumor Dormancy: Can Platelet Content Serve as Predictive Biomarker for Exit of Tumors from Dormancy?

Cancers 2010 2(2):842-858. Doi: 10.3390/cancers2020842.

Etulain J, Lapponi MJ, Patrucchi SJ, Romaniuk MA, Benzadon R, Klement GL, Negrotto S, Schattner M.

Hyperthermia inhibits platelet hemostatic functions and selectively regulates the release of alpha-granule proteins.

J Thromb Haemost. 2011 Aug; 9 (8): 1562-71. doi: 10.1111/j.15387836.2011.04394.x. PMID:21649851

Downing SR, Klement GL.

Isolation and proteomic analysis of platelets by SELDI-TOF MS.

Methods Mol Biol. 2012;818:153-70. doi: 10.1007/978-1-61779-418-6_12. PMID: 22083823
Peterson JE, Zurakowski D, Italiano JE Jr, Michel LV, Connors S, Oenick M, D'Amato RJ, Klement GL, Folkman J.
VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients.
Angiogenesis. 2012 Jun;15(2):265-73. doi:10.1007/s10456-012-9259-z. Epub 2012 Mar 9. PMID: 22402885
Klement GL, Goukassian D, Hlatky L, Carrozza J, Morgan JP, Yan X
Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart.
Front Pharmacol. 2012; 3: 113. Published online 2012 June 27. doi: 10.3389/fphar.2012.00113 PMCID: PMC3384262
Mayer EL, Isakoff SJ, Klement G, Downing SR, Chen WY, Hannagan K, Gelman R, Winer EP, Burstein HJ.
Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomics.
Breast Cancer Res Treat. 2012 Nov;136(1):169-78. doi: 10.1007/s10549-012-2256-5. Epub 2012 Sep 23. PMID: 23001754
Hahnfeldt P, Hlatky L, Klement GL
Center of cancer systems biology second annual workshop--tumor metronomics: timing and dose level dynamics
Cancer Res. 2013 May 15;73(10):2949-54. doi: 10.1158/0008-5472.CAN-12-3807. Epub 2013 Mar 14. PMID: 23492368
Pilatova K, Greplova K, Demlova R, Bencsikova B, Klement GL, Zdrazilova-Dubska L
Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology.
J Hematol Oncol. 2013; 6: 42. Published online 2013 June 24. doi: 10.1186/1756-8722-6-42